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Those who are concerned or particularly sensitive can request additional pre-injection numbing injections with lidocaine or can use ice prior to injection to numb the treatment area (avoiding the initial pin-prick of Vollure)

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doi: 10.3389/fcimb.2026.1752304 Received 23 November 2025 Revised 12 January 2026 Accepted 31 January 2026 Published 19 February 2026 Volume 16 - 2026 Edited by Teclegiorgis Gebremariam, Lundquist Institute for Biomedical Innovation, United States Reviewed by Fatemeh Ahangarkani, 4cyte Pathology, Australia Sanam Dolati, Lundquist Institute for Biomedical Innovation, United States Updates Copyright 2026 Wu, Jiang, Wang, Chen, Chen and Da

doi: 10.3945/an.114.007732

found that, in diabetic ulcers, the levels of ROS, MDA, and lipid peroxidation in fibroblasts and vascular endothelial cells subjected to high glucose settings are significantly increased [189]