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A systematic review analyzing zinc supplementation in PCOS found that doses ranging from 4 to 50 mg daily for 8 to 12 weeks resulted in improvements in insulin resistance (HOMA-IR) and lipid profiles while also reducing inflammatory markers such as hs-CRP and oxidative stress markers like malondialdehyde (MDA) and TAC [153]
Peer review Peer review information Nature Catalysis thanks Mattheos Koffas, Bengt Mannervik, Boas Pucker, Dingguo Xu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
This challenges the prevailing notion that antioxidants generally benefit health, especially in cancer
10.1038/s41467-023-43605-4 [DOI] [PMC free article] [PubMed] [Google Scholar] 63.Mauvais-Jarvis F, Sobngwi E, Porcher R et al (2004) Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance
Thereafter, the antioxidants curcumin and glutathione are covered, which are traditionally recognized as important owing to health-promoting benefits
[DOI] [PubMed] [Google Scholar] [31].Khan SA, Campbell AM, Lu Y, An L, Alpert JS, Chen QM
