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Although results from several recent clinical trials do not show promise as anti-c-Met drugs, a combined therapeutic strategy for multiple downstream signal transduction could have clinical potential, especially in c-Met-positive patients

This route allows slow, sustained absorption into the bloodstream

Chemotherapy combined with sorafenib can effectively reduce serum HIF-1 and VEGF levels in patients with GC to improve their 1-year survival rate and prognosis (116)

Applications in adipocyte and metabolic research models

Oncogene 27 , 70947105 (2008)

But it stressed that dose-response relationships were not established and that there is insufficient clinical safety information to characterize BPC-157's human safety profile with no studies administering it to humans by the proposed routes