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Additionally, environmental stressors like heavy metals and pesticides have been shown in experimental models to impair proteasome function, promote syn aggregation, and drive dopaminergic neuron loss, underscoring the multifaceted contribution of UPS impairment to PD pathogenesis [170]

The protease-activated receptor 2 regulates pigmentation via keratinocyte-melanocyte interactions
Derakhshan, A

albicans infection and therapeutic responses, with the Dectin-1/CARD9/IL-17 signaling pathways emerging as the most clinically relevant axes

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Remodeling of the immune response with aging: immunosenescence and its potential impact on COVID-19 immune response