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Although SASP contributes markedly to inflammaging, its effect is not limited to this, but is of a complex pleiotropic nature, which has been explained in detail in the recent review by Birch and Gil [46]

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, et al

Nonetheless, in organotypic hippocampal cultures with preserved neuronal-glial interactions roxadustat decreased the neuronal susceptibility to ischemic stress, which was largely prevented by restricting glycolytic energy production through lactate transport blockade
doi: 10.1016/j.ygyno.2004.10.012
