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10.1038/s41586-019-1705-2 8 Bosello-TravainV.ConradM.CozzaG.NegroA.QuartesanS.RossettoM.et al (2013)

337 Although all cell types responded to this inhibitor in vitro and showed promising therapeutic effects in vivo, 337 phase I clinical trials for treating advanced solid tumors ultimately failed due to cardiovascular toxicity and wide variability in patient responses

Clinically, high NRF2 expression in HCC is associated with larger tumor size, vascular invasion, poor differentiation, and decreased overall survival

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Leukemia 36 , 23512367 (2022)