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Cardiotoxicity attenuation has been studied in the context of bupivacaine exposure (PMID 27815173), broadening the literature beyond the conventional musculoskeletal and gastric framings
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Most enzymes and factors implicated in the tricarboxylic acid cycle contain iron, or can only function in the presence of iron
The synergy claim is mechanistic, derived from the three peptides acting on different nodes of overlapping pathways (VEGF, NF-kB, ECM remodeling)
