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While it's calming inflammatory signals, it's simultaneously neutralizing those pesky free radicals that trigger and perpetuate inflammation in the first place

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Hepatoma Res 4:39 Gao T, Wang T, Wang Z, Cao J, Dong Y, Chen Y (2021) Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/ROR/NF-B signaling pathways