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Most patients begin noticing cognitive improvements within the first two to three weeks, with full benefits building over the complete 8-week active phase

doi:10.1016/j.jep.2016.05.010 Cases J, Ibarra A, Feuillere N, Roller M, Sukkar SG

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If you are already stable on bupropion, you can proceed to start tirzepatide while continuing bupropion at your current dose
