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The unique pharmacological profile of tirzepatide allows a greater engagement of the GIP receptor, mimicking the actions of native GIP, compared to the GLP-1 receptor, where it activates biased downstream signals favoring cAMP generation over beta-arrestin recruitment, resulting in reduced receptor internalization and degradation 2

This helps explain why diet, fiber intake, and overall gut health can play a role in appetite regulation

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Park JJ

Reflection In the first quarter of 2025, the agency has approved 7 novel drugs which is 30% less that the number of approvals about the same time last year

In this study, by performing metabolomic and metagenomic analyses in a cohort of atherosclerotic patients receiving atorvastatin, the Clostridium species were identified to be closely associated with bile acid synthesis and excretion in a time-dependent manner