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A retrospective study looking at concomitant use of proton pump inhibitors (PPIs) alongside metformin in 614 people with type 2 diabetes in the US found a significant reduction in B12 levels of 34% in patients taking both medications, compared to controls taking either drug alone (Long et al, 2012)

Fat Metabolism by Facilitating Fatty Acid Transport into Mitochondria in Muscle Fibers

International Journal of Molecular Sciences, 24 (3), Article 2633

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