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[145] [147] [166] In particular, aerobic exercise decreases psychostimulant self-administration, reduces the reinstatement (i.e., relapse) of drug-seeking, and induces increased dopamine receptor D 2 (DRD2) density in the striatum

Mast cells (MCs) are stimulated and degranulate, releasing histamine, IL-6, IL-8, prostaglandin D2 and tumor necrosis factor-alpha (TNF)- together with IL-23 and IL-31 and other cytokines (48, 49)