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Negative effects of alcohol 2 that contribute to a hangover include: Accumulation of toxic byproducts, including acetaldehyde Nutrient depletion Hormonal imbalances, including increased cortisol (a stress hormone) and lower serotonin (affecting your mood) Dehydration Inflammation Poor sleep quality When you drink, your liver works overtime to metabolize alcohol into acetaldehyde, a toxic byproduct that contributes to hangover symptoms, including headaches, nausea, and fatigue

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doi: 10.3390/ijms20153763

Scalbert A, Johnson IT, Saltmarsh M

In clinical trials, oral l-glutamine reduced painful sickling crises by 25% and hospital admission by 33%

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