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Carmi, Y

Common side effects for both include mild injection-site reactions, transient water retention, and occasionally a 'flushing' sensation immediately after injection

Many different factors can cause aches, pains, and inflammation

PMID 21548867
Although the anti-inflammatory effects of the CB 2 R are well-characterized, it is also important to note that the CB 2 R seems essential for many environmental-induced immune responses in microglia

Lions mane has growing interest and some RCT evidence, but its still early and not definitive
