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These same principles could be extended to the design of inhaled peptide and protein therapies aimed at navigating or modulating the mucus barrier, particularly by integrating aerodynamic design with mucus-penetrating or mucus-protective features

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In fact, the use of GSTP1 knockout mice demonstrated that loss of GSTP1 expression increases sensitivity to metabolic or environmental toxins and promotes mutations and cancer development (Coughlin and Hall, 2002a,b)

N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic pain

The drug reduces hepatic glucose production, enhances glucose uptake in the peripheral tissues and increases insulin sensitivity 115

J Mol Cell Cardiol 53:858869