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Therefore, to enhance mitochondrial complex I activity, NAD + levels were boosted in fly models of PD with NAM, leading to reduced oxidative stress, including lower ROS levels and DNA damage, as well as improved climbing ability 281

Loss of Unc5B decreases BBB Wnt/catenin signaling, and -catenin overexpression rescues Unc5B mutant BBB defects

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Madl T, et al

When these peptides were co-administered into the peritoneum of baboons with endometriosis, cells in lesions selectively underwent apoptosis with no effect on neighbouring organs
