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The cytostatic at a dose of 7 mg/kg were intraperitoneally administered to the animals, and the physiological solution was intrana- sally administered instead of the peptide

Implications for clinical therapy Although, overall, both insulin sensitivity and beta-cell secretion are expected to improve with lowered glucose, HOMA-IR measurements over 8 weeks cannot be used to evaluate the effectiveness of treatment for an individual

doi: 10.1161/01.res.0000163017.13772.3a

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4-PBA might therefore be a suitable candidate drug for treating the leptin resistance that is induced by endoplasmic reticulum stress