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However, compared with humans, the ratio of the oral dose to the serum concentration seems to be higher in rats than in humans, making it difficult to directly apply relevant studies to humans (Meftah et al., 2021)

Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH

69 (3), e141e142 (2013)

[DOI] [PubMed] [Google Scholar] 77.Ozcankaya R., Delibas N

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