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The sub-30-minute plasma half-life is the pharmacokinetic basis for twice-daily dosing, though no human study has confirmed this produces better outcomes

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Modelers should run separate survival probability curves for each patent layer, discount the thicket premium by the probability of successful PTAB challenge (roughly 39% institution denial for biologics, per current USPTO data), and adjust for political risk around patent cap legislation like S.150 or the Affordable Prescriptions for Patients Act