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Methylation is one of the key Phase II processes that packages estrogen metabolites for elimination

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Although results of studies carried out to date do not confirm associations between GSTM1 , GSTT1 , and GSTP1 and epithelial ovarian cancer, the associations are biologically plausible because glutathione S -transferases metabolize exogenous and endogenous substances that may have a role in ovarian cancer carcinogenesis

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The binding of ritonavir to Mrp1 may therefore increase the affinity of GSH for the H-Pocket of Mrp1, thereby enhancing GSH binding and lowering the K m value for GSH transport

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Jun 2007;56(6):1703-1711

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Pancreas 36:e1e14

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Academic References Ramanathan R, Desrouleaux R

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