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Cellular senescence: mechanisms and therapeutic potential

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92,93 Valsartan is combined with neprilysin in heart failure therapy, where neprilysin additionally reduces senescence biomarker insulin-like growth factor-binding protein-7 (IGFBP-7) in heart failure with preserved ejection fraction (HFpEF) patients when compared with the ARB alone

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Semax has extensive clinical use in Russia for stroke treatment and cognitive enhancement, with data supporting its mood effects primarily from preclinical research and clinical observation rather than large randomized trials specifically designed to test antidepressant efficacy