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However, the availability of data on guiding anticoagulants in AF patients with elevated TMAO is still limited

Rather than performing direct LDL-C measurements in all patients, recent guidelines recommend direct measurement of LDL-C when triglyceride concentrations exceed 4.5 mmol/L or when LDL-C concentrations are below 1.3 mmol/L or 1.8 mmol/L ( 1 - 4 )

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Transcriptional control The rate of synthesis of HMG-CoA reductase messenger RNA (mRNA) is controlled by one of the family of sterol-regulatory element-binding proteins (SREBPs)