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[DOI] [PMC free article] [PubMed] [Google Scholar] 175.Palma BD, Gabriel A, Jr., Colugnati FA, Tufik S

While these findings clearly support a major role of autoimmunity in SSc genetics, it is less clear whether these SSc susceptibility loci are directly involved in SSc skin fibrosis

Moreover, the cytokine signatures have potential as biomarkers to differentiate the two types of IBD as CD primarily expresses Th1- and Th17-associated cytokines (IL-17, -23 and -32), whereas UC is an atypical Th2-with low IL-4 and high IL-5, -13, -15 and -33 [70]