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Both OAT and PYCR1 are markedly elevated in IPF lung tissues and fibroblasts, with their expression levels correlating with deteriorating lung function and poor prognosis [71, 72]

In this context, citrate is transported out of the mitochondria into the cytosol via the mitochondrial citrate carrier SLC25a1 and - with the help of ATP citrate lyase functions as an acetyl donor to support the generation of acetyl CoA and fatty acid-derived derivatives

Structural changes in collagen and elastin networks require sustained signaling to manifest fully

Another approach is treated in the publications Westerhoff et al

Ozone therapy for the treatment of chronic wounds: a systematic review