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Quantification of ROS in PBMC from healthy subjects, patients with newly diagnosed Graves disease or treated with methimazole (A), or in PBMC from patients with newly diagnosed Graves disease incubated with NAC (2mM) for 24h (B)

One potent strategy is to combine NRF2 inhibitors with cisplatin, which not only elevates intracellular ROS levels but also obscures the cancer cells ability to respond to oxidative stress [210,211,212]

This finding is consistent with other reports that these genes expression typically peaks during early progenitor stage and decreases towards the final hepatocyte-like cells stage 24,25,26

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CPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage