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10.1186/s12943-020-01168-8 117 ZhangH.WangM.HeY.DengT.LiuR.WangW.et al (2021)

Additionally, pharmacologically improving fatty acid use by TILs with peroxisome proliferator-activated receptor agonists enhances anti-tumor immunity and responses to ICB 188, 189

GSH peroxidase 4 (GPX4) utilizes GSH to reduce lipid peroxides to innocuous lipid alcohols, thereby shielding cells from ferroptotic damage (Seibt et al

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192 Studies have shown that Fusobacterium nucleatum promotes the occurrence and development of UC by destroying the normal intestinal structure, downregulating the level of tight junction proteins, promoting the apoptosis of intestinal epithelial cells, increasing the expression of inflammatory cytokines, and disrupting the balance of the intestinal microbiota
Programmed Cell Death Tunes Tumor Immunity