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Strategies for the identification of bioactive neuropeptides in vertebrates

However, combining MK-677 with injectable secretagogues typically offers minimal additional benefit and may amplify unwanted effects

Dis Colon Rectum 62(3):274-278, 2019
doi: 10.1016/j.phymed.2018.09.209 34 GuoPXueMTengXWangYRenRHanJet al

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Current behavioral and pharmacotherapies to reduce appetite and counter body weight gain have shown limited success in part due to resilience of the organism to adapt to changes in energy homeostasis 1,2