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Description
For HIF transcription factors, this occurs by hydroxylation at conserved proline residues by prolyl hydroxylases under normoxia, allowing their recognition and ubiquitination by the VHL E3 ubiquitin ligase, which targets HIFs for proteasomal degradation
Gu YY, Liu XS, Huang XR, Yu XQ, Lan HY
For details, see Dr
M.TomaroM
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In the past, type I IFNs (II-IFNs) were considered to play the most crucial role in the pathogenesis of SLE (169)
