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Methodological differences, outcome measure variability, incomplete reporting, biological confounders, and overgeneralization of the results made evaluating innovative pharmacological agents challenging

Glutathione reductase (GR) is a flavoenzyme whose main function is to catalyze the reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH), playing a crucial role in the redox balance of cells.

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This study provides the first mechanistic evidence that GHK-Cu delays aging through coordinated regulation of mitochondrial function and activation of both DAF-16 and SKN-1 pathways

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