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Although these findings suggest potential benefits of GABA-related interventionsgiven carnosines proposed modulation of GABAergic activity and zinc/copper homeostasisthe mechanism remains unclear, and replication in larger, independent samples is needed (183)

Labile thiosulfinates such as allicin are best suited to local delivery (topical, inhaled, or GI-targeted) to achieve local PK/PD effects while limiting systemic off-target thiol reactivity

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Even though each heavy metal has a specific mechanism of toxicity, there are common unifying toxicity characteristics for certain groups of heavy metals outlined below

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Necroptosis and apoptosis contribute to cisplatin and aminoglycoside ototoxicity