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Then using a H 2 O 2 -induced senescent TM3 Leydig cell model, we found that FOXO4 maintains the viability of senescent Leydig cells and that the FOXO4 blocker FOXO4-DRI induces apoptosis in these senescent cells

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This was observed in additional research

Cummings JL, Schneider E, Tariot PN, Graham SM, Memantine MEMMD02 Study Group