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Importantly, the membrane composition and especially the presence of cholesterol has to be considered (Nagle, 2021

declares having received research funding (paid to institution) from Novo Nordisk, Sanofi, Mylan and Boehringer Ingelheim

The rationale is that combination therapy may more closely replicate the physiological secretion ratio of T4 to T3 (approximately 13:1 by weight), potentially restoring a more physiological FT3/FT4 balance (43)

Beside classical inflammatory related markers such as acute phase proteins (CRP and globulins), also parameters that reflect changes in certain bone marrow lineages such as PLR and NLR have been described 2,5

Storkebaum E, Carmeliet P (2004) VEGF: a critical player in neurodegeneration