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[31] A 2025 review reported that theanine research has lacked rigor, was mainly based on anecdotes, had ill-defined mechanisms, and exhibited unreliable clinical trials

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The remaining six studies were conducted at 7T in the following ROIs: corona radiata white matter (WM) (van de Bank et al., 2015), and the cingulate (medial pregenual anterior, posterior) (Gonen et al., 2020, Lally et al., 2016, van de Bank et al., 2015), occipital (Prinsen et al., 2017), precuneal (Gonen et al., 2020), motor (Lim and Xin, 2022), medial prefrontal (Lim and Xin, 2022) and/or the dorsolateral prefrontal (Reid et al., 2022) cortices