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V 1985 Sies Redox framework Dsseldorf Helmut Sies, working at the University of Dsseldorf, formulates the broader conceptual framework of cellular oxidant-and-antioxidant balance integrating decades of accumulated observation on glutathione biology into a coherent cellular framework that the field continues to work within

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Without adequate amounts of glutathione, toxins like free radicals would accumulate in fat stores