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Most research studies have shown that intranasally administered lipophilic compounds improve CNS bioavailability and reduce the time for the onset of therapeutic response

Zhiguang Sun, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Combining them, they form even greater protection against oxidative damage

2 10 The unsaturated acyl chains in membrane phospholipids and cholesterol in membranes, among biomolecules, are highly susceptible to pathologic free radical damage for the following reasons 16 : First, the inherent structure of polyunsaturated fatty acid chains (polyunsaturated acyl chains are normally unconjugated, and the alpha-methylenic carbons between carbons with double bonds have allylic hydrogen that can readily enter into free radical reaction

Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimers disease

New insights into glioblastoma