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As such, a recent paper described the concept of dynamic bias, which refers to changes in a biologic system due to alterations in physiologic and pathophysiological factors over time like aging, disease, or medications (Michel et al., 2014)

To date, a total of 54 patients with mutations in the PLPBP gene have been reported, with approximately 63% of them have consanguineous parents [6]

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Extended continuous use can reduce receptor sensitivity and potentially cause copper accumulation concerns