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A mixture of appropriate quinoline derivative (approximately 1 equiv) and methyl trifluoromethansulfonate (MeOTf) (approximately 3 equiv, unless otherwise indicated) in toluene (0.2M) was heated at 100 C

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There is a spreadsheet available to keep track of his glucose readings

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Numbness or tingling in hands and feet Peripheral nerve changes are a more serious sign of prolonged deficiency