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At the clinic level this translates in a much smaller reach of the care provided, compared to the patient population needing help to conceive

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In addition to limited absorption via the IF, the intake of high-dose supplements leads to passive diffusion, i.e., the vitamin can freely enter the bloodstream without IF binding and receptor uptake

A peer-reviewed study in the Journal of Clinical Endocrinology and Metabolism by Prinz and colleagues demonstrating that acute alcohol intake produces a significant suppression of nocturnal growth hormone secretion alongside reduced slow-wave sleep has been the foundational reference for this effect for decades, and the relationship has been replicated in newer literature on adult sleep architecture

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