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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility

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This mesolimbic-cerebellar pathway forms a neuroanatomical interface between motivational-affective processing and cerebellar circuits, implicating the cerebellum in reinforcement learning and the drive for analgesia (5961)

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