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However, as this yolk granule/lysosomal defect gets more severe in the absence of CUP-5, it indirectly impacts the trafficking of some gut granule proteins

The ArfGEF GBF-1 is required for ER structure, secretion and endocytic transport in C

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Wang H, Wei H, Zhao M, Wu J, Fei M, Lin N, et al

[DOI] [PubMed] [Google Scholar] Hummer M, Kurz M, Kurzthaler I, et al

Broad categories include proximal SMA and distal SMA (DSMA, also known as hereditary motor neuropathy or dHMN), demonstrating considerable genetic and clinical heterogeneity
