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It acts as a non-selective agonist at MC1R, MC3R, MC4R, and MC5R, with particularly high potency at MC1R, the receptor governing melanogenesis in epidermal melanocytes

Hereditary disorders like neurofibromatosis 2 (NF2), schwannomatosis, or Carney complex trigger schwannomas

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[DOI] [PubMed] [Google Scholar] Harkin C., Smith K
If this does occur, the time this sensation lasts varies by patient, with some people feeling numb for a few hours and others feeling numb for several weeks
