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A study had showed that resveratrol inhibits ferroptosis by ameliorating LPS-induced cardiomyocyte injury with upregulation of miR-149 and downregulation of high-mobility group box protein 1 (141)

Increased ferric iron content and iron-induced oxidative stress in the brains of scrapie-infected mice

J Nat Med (2014) 68:41420

This creates a pharmacokinetic advantage: higher hippocampal exposure with lower systemic exposure reduces the risk of peripheral side effects while maintaining therapeutic receptor activation

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