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Sleep deprivation studies have provided firsthand evidence in support of the free radical flux theory that sleep promotes clearance of overloaded free radicals, protecting the brain against cellular damage and neurodegenerative diseases as well as age-associated pathology (Hill et al., 2018

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Although this isoform is not directly related to drug metabolism, it is associated with liver dysfunction due to the accumulation of bile acids, which could disrupt enterohepatic recirculation and, therefore, indirectly affect drug metabolism (Zhang et al., 2015)