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In addition, the alteration of GAPDH and PK in AD was further described by an immunoproteomic approach that demonstrated the presence in the CSF of autoantibodies against these enzymes (397), consistent with the notion that proteins undergoing ox-PTMs become toxic to neurons, which induce clearance systems and immune responses

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In cancer, epigenetic modulation of OCTN2 may be applied to enhance the effectiveness of anticancer compounds [68, 69]
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