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The good news is that they are minor and temporary
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6E), suggesting heightened cell death under these complex co-culture conditions
Involved in cellular signaling and regulating calcium levels, CD38 degrades NAD + , using it as a co-substrate for its enzymatic activity 135,136
In highly hypoxic TMEs, especially PC cells, can also take up biomacromolecules required for anabolism by adjacent cancer cells with high glycolytic flux (230)
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