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Reactive oxygen species such as the SO anion, H 2 O 2 , and the hydroxyl radical are formed by water-soluble constituents of tar, and can damage fundamental parts of cells and DNA

Mitochondrial damage is often defined as a deviation of respiratory parameters or states, which were originally defined in vitro using isolated mitochondria 80,81,82

Glutathione helps neutralize that damage before it builds up

Nerve damage involves inflammation, vascular compromise, neurotrophic factor deficiency, oxidative stress, and mitochondrial dysfunction

Phospholipids (PL) are converted into lipid biomarkers under the action of phospholipases and ROS, which are activated or released under specific physiological and pathophysiological conditions, potentially implicating them in ARDS regulation

Pollution and respiratory disease: can diet or supplements help