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Wakamatsu, K

Under hypoxia, STAT3 forms transcriptional complexes with HIF1, CBP/p300, and Ref-1/APE to enhance VEGF expression, as observed in multiple cancers

Marcocci ME, Amatore D, Villa S, et al
Immune Function: Glutathione supports the immune system by promoting the proliferation of lymphocytes and enhancing their activity

Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations

However, in AD, tau becomes hyperphosphorylated to detach from microtubules and form toxic neurofibrillary tangles that impair cellular transport and accelerate neuronal death (Ye et al., 2025)
