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This degradation releases NF-B from the IB complex, facilitating its translocation to the nucleus, where it binds to the promoter region of target genes, including Il-6 , to activate their transcription 29

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Topically applied curcumin-loaded nanoparticles treat erectile dysfunction in a rat model of type-2 diabetes

10.1016/j.ejogrb.2022.07.017 39 FloryJ.LipskaK

Temporal scaling of lifespan is not evident when ferroptosis is inhibited, consistent with this cell death process acting at specific life phases to induce organismal frailty, rather than contributing to a constant aging rate

Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration