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Undesirable symptoms of drug addiction include increased tolerance to intoxicating substances, continuing drug use despite unpleasant health, mental, and social consequences, and the appearance of withdrawal syndrome such as hand and muscle tremors, excessive sweating, irritability, hallucinations, depression, concentration deterioration, and anxiety

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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious or beneficial to biological systems