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Genetic determinants of statin intolerance

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Redox homeostasis, oxidative stress and mitophagy

SIRT3 expression is downregulated in obese patients, and deletion of SIRT3 leads to increased mitochondrial oxidative stress, reduced energy expenditure and worsened glucose metabolism, resulting in accelerated obesity under a high-fat diet (HFD) feeding [25, 26]

The bark contains methyl salicylate which is a weak acting precursor to the salicylic acid that is used in aspirin, but much less irritating to the gastric mucosa

Residual cholesterol and inflammatory risk in statin-treated patients undergoing percutaneous coronary intervention